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Fig. 4 | Future Journal of Pharmaceutical Sciences

Fig. 4

From: Application of SeDeM Expert System in the development of novel directly compressible co-processed excipients via co-processing

Fig. 4

Application of SeDeM Expert System in particle engineering design space of co-processed excipients. Stage I involves the characterization of Critical Material Attributes (CMAs) of both defective and corrective materials using SeDeM methodology [a]. Stage II: Computing the loading capacity of the corrective excipient using dilution potential equation proposed by the SeDeM Expert System [b]. Stage III: Selection of co-processing technique based on intrinsic material property and desired CMAs [c]. Stage IV: Evaluating the impact of co-processing by monitoring the critical behavior of the engineered composite with the decision on either to accept or reject the product [d]. Upon failing to meet up with the critical specifications or acceptance criteria, the process conditions in Stage III can be revalidated or modified. IPP: Parametric Profile Index, IGC: Good Compression Index, ψc: Compressibility function, ѱf: Flowability function

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