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Future Journal of Pharmaceutical Sciences

Table 14 Molinspiration calculation of Tezacaftor and its metabolites

From: A rapid RP-HPLC method for the simultaneous estimation of Ivacaftor and Tezacaftor and in silico study of their metabolitic products

Name

miLogP

TPSA

Natoms

MW

Nrotb

Volume

Tezacaftor

2.8

111.49

36

510.51

10

435.38

Tezacaftor M1

3.97

102.19

37

518.49

4

424.95

Tezacaftor M2

3.39

130.25

38

534.49

8

436.98

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