Table 17 Predicted molecular pharmacokinetic properties of Ivacaftor and its metabolites using Swiss ADME database
Name | GI absorption | BBB permeant | P-gp substrate | CYP1A2 Inhibitor | CYP2C19 Inhibitor | CYP2C9 Inhibitor | CYP2D6 Inhibitor | CYP3A4 Inhibitor |
|---|---|---|---|---|---|---|---|---|
Ivacaftor | High | No | No | No | Yes | No | No | Yes |
Ivacaftor M1 | High | No | No | Yes | No | No | Yes | No |
Ivacaftor M6 | High | No | No | Yes | No | No | No | No |