Table 18 Predicted molecular pharmacokinetic properties of Tezacaftor and their metabolites using Swiss ADME database
Name | GI absorption | BBB permeant | P-gp substrate | CYP1A2 Inhibitor | CYP2C19 Inhibitor | CYP2C9 Inhibitor | CYP2D6 Inhibitor | CYP3A4 Inhibitor |
|---|---|---|---|---|---|---|---|---|
Tezacaftor | High | No | Yes | No | No | No | No | No |
Tezacaftor M1 | High | No | Yes | No | No | Yes | Yes | Yes |
Tezacaftor M2 | Low | No | Yes | No | No | Yes | Yes | Yes |