Table 19 Predicted molecular toxicity of Ivacaftor and its metabolites using data warrior
Name | Mutagenic | Tumorigenic | Reproductive | Irritant | ORAT | ORCT | Hepatotoxicity |
|---|---|---|---|---|---|---|---|
Ivacaftor | None | None | None | None | 2.073mol/kg | 2.022log mg/kg | Yes |
Ivacaftor M1 | None | None | None | None | 2.149mol/kg | 2.298log mg/kg | Yes |
Ivacaftor M6 | None | None | None | None | 2.428mol/kg | 2.826log mg/kg | Yes |