Table 20 Predicted molecular toxicity of Tezacaftor and its metabolites using data warrior
Name | Mutagenic | Tumorigenic | Reproductive | Irritant | ORAT | ORCT | Hepatotoxicity |
|---|---|---|---|---|---|---|---|
Tezacaftor | None | None | None | High | 3.732 mol/kg | 2.997log mg/kg | Yes |
Tezacaftor M1 | None | None | None | High | 2.963 mol/kg | 1.814log mg/kg | Yes |
Tezacaftor M2 | None | None | None | High | 2.966 mol/kg | 3.963log mg/kg | Yes |