A new stability-indicating RP-HPLC method for the determination of dicyclomine hydrochloride and dimethicone combination in tablet dosage forms

Future Journal of Pharmaceutical Sciences

Table 1 DEC and DEH system suitability

Values	ReT	ReA	ReS	PCS	TF	K’	HETP	α’
Dicyclomine hydrochloride
Avg^a	2.127	2173795	–	4477	1.436	1.127	0.056	Avg^a 1.648
SV	0.0081	5667.4136	–	39.8535	0.0089	0.0079	0.0005	Avg^a 1.648
RSV	0.381	0.261	–	0.890	0.623	0.701	0.887	SV 0.0039
Dimethicone								SV 0.0039
Avg^a	2.858	4249950	4.920	4954	1.294	1.858	0.050	RSV 0.237
SV	0.0088	7331.8554	0.0141	30.4844	0.0055	0.0093	0.0003	RSV 0.237
RSV	0.309	0.173	0.287	0.615	0.423	0.499	0.636

SV standard variation, RSV relative standard variation, ReT retention time, ReA response area, ReS resolution, PCS plate counts, TF tailing factor, K’ capacity factor, HETP height equivalent to theoretical plates, α’ selectivity factor
^aAverage of five estimates