A new stability-indicating RP-HPLC method for the determination of dicyclomine hydrochloride and dimethicone combination in tablet dosage forms

Future Journal of Pharmaceutical Sciences

Table 5 Degradation and specificity values for DEC and DEH

Stress conditions put in	Drug	Peak response	Degradation (%)	Peak purity
Stress conditions put in	Drug	Peak response	Degradation (%)	Angle	Threshold
Control without degradation	DEH	2173795	–	–	–
Control without degradation	DEC	4249950	–	–	–
0.1N HCl	DEH	1991167	8.64	0.349	0.560
0.1N HCl	DEC	3801785	10.9	0.266	0.458
0.1N NaOH	DEH	2038512	6.41	0.264	0.659
0.1N NaOH	DEC	3951346	7.40	0.380	0.759
30% peroxide	DEH	2064601	5.21	0.255	0.761
30% peroxide	DEC	3975288	6.84	0.278	0.659
60°C Temp.	DEH	1933228	11.24	0.238	0.661
60°C Temp.	DEC	3850464	9.76	0.386	0.859
Sunlight	DEH	2030208	6.79	0.354	0.763
Sunlight	DEC	3908982	8.39	0.293	0.660