Cocrystallization of gliclazide with improved physicochemical properties

Future Journal of Pharmaceutical Sciences

Table 1 Reported cocrystallization with gliclazide using different coformers

S.l No.	Coformers	Technique of preparation	Solubility enhancement	Reference
1.	Tromethamine	Solvent evaporation, kneading, dry grinding	⁓ 4 fold	[30]
2.	Succinic acid, malic acid	Liquid-assisted grinding method (LAG)	2-fold 2-fold	[31]
3.	Sebacic acid, α-hydroxyacetic acid	LAG LAG	2.4-fold 3-fold	[32]
4.	Malonic acid	Co-precipitation	29.17-fold	[33]
5.	Catechol, resorcinol	LAG LAG	6.07-fold 3.51-fold	[34]
6.	Piperazine	LAG	6.58-fold	[34]
7.	Metformin	LAG	1.16-fold	[35]
8.	Benzamidine	Ball milling	Dissolution enhanced	[36]