Skip to main content

Table 3 Statistical optimization analysis of sofosbuvir, velpatasvir, ledipasvir, and daclatasvir

From: Multivariate optimization and evaluation of quaternary mixture in bulk and co-formulated dosage forms by central composite design

S.No

Combination

Sofosbuvir

Velpatasvir

Ledipasvir

Daclatasvir

Coefficient

SS ratio

Coefficient

SS ratio

Coefficient

SS ratio

Coefficient

SS ratio

1

b0

10,471.73

3758.796

2708.256

2708.857

2

b1

−5687.915

85.8153%

2802.296

90.1972%

1742.631

90.942%

1751.607

56.360%

3

b2

1464.595

5.6898%

237.662

0.6488%

94.328

0.2665%

815.147

12.206%

4

b12

475.782

0.6004%

233.662

0.6271%

88.453

0.2343%

819.897

12.348%

5

b3

−1482.62

5.8307%

−588.4863

3.9778%

−367.111

4.036%

−52.675

0.051%

6

b13

664.927

1.1728%

−618.486

4.3936%

−372.736

4.1606%

−64.925

0.0774%

7

b23

−367.687

0.3586%

−83.006

0.0791%

−77.078

0.1779%

−726.135

9.685%

8

b123

−448.05

0.5325

−81.506

0.0763%

−77.953

0.182%

−710.385

9.2702%

  1. SS sum of squares