Table 2 In vitro permeation parameters of CV from single-layer drug-in-adhesive formulations (mean ± SD, n = 3)
Formulation code | Time of drug permeation (h) | Flux (mg/cm2/h) | Permeability coefficient (cm/h × 10−2) |
|---|---|---|---|
S1 | Up to 48 h | 19.11 ± 0.03 | 32.9 ± 0.02 |
S2 | Up to 48 h | 16.23 ± 0.05 | 22.7 ± 0. 03 |
S3 | Up to 30 h | 18.13 ± 0.04 | 27.6 ± 0.03 |
S4 | Up to 48 h | 18.05 ± 0.15 | 29.3 ± 0.06 |
S5 | Up to 48 h | 15.18 ± 0.02 | 20.1 ± 0.06 |