Design, synthesis and biological evaluation of substituted pyrazoles endowed with brominated 4-methyl 7-hydroxy coumarin as new scaffolds against Alzheimer’s disease

Future Journal of Pharmaceutical Sciences

Table 3 Effect of compound D1 on brain acetylcholine esterase level

Sl no.	Group	Mean AchE level in μ/ML
1	Negative control (l% w/v CMC )	0.3843 ± 0.03237***
2	Toxic control (scopolamine (0.4mg/kg)	0.7002 ± 0.01101
3	Standard (donepezil hydrochloride 5mg/kg)	0.5003 ± 0.002883***
4	Lower dose (scopolamine + compoundD₁200Mg/Kg)	0.5943 ± 0.01065
5	Higher dose (scopolamine + compound D1(400mg/kg)	0.5250 ± 0.006851

Values are the mean ± SEM, n = 6, ***significant at p < 0.001,**significant at p < 0.01 compared to toxic control. Data were analysed by one-way ANOVA followed by Dennett’s multiple comparison test