Table 1 The two-dimensional (2D) structures of the newly designed NSCLC drugs
S/NO | Structures | Predicted pIC50 | Binding affinities |
|---|---|---|---|
SFD1 |
| 11.09261 | − 8.8 |
SFD2 |
| 10.31956 | − 9 |
SFD3 |
| 10.72999 | − 9 |
SFD4 |
| 10.28596 | − 9.2 |
SFD5 |
| 7.746966 | − 9 |
SFD6 |
| 10.33485 | − 8.9 |
SFD7 |
| 10.14274 | − 9.1 |
SFD8 |
| 10.33904 | − 9.3 |
SFD9 |
| 10.26403 | − 9.2 |
SFD10 |
| 8.297705 | − 9.5 |
Gefitinib |
| 5.879426 | − 7.5 |
