Table 2 Comparative analysis of nanomaterials of curcumin and hyaluronic acid therapy with curcumin therapies
Activity | Curcumin only | Cur-H.A | Description |
|---|---|---|---|
Breast cancer | Curcumin: applied as oral dose [73] | Hybrid nanoparticles [74] | Yang et al. applied combination therapy with paclitaxel (PTX), a chemotherapeutic agent and curcumin using HA-hybrid NPs that expressed a potential strategy for inhibiting breast tumor growth by killing breast cancer stem cells (bCSCs) and non-CSCs. |
Colorectal, colorectal cancer | Curcumin: nanoformulations and with chemotherapy agents [75, 76] | Xiao et al. reported curcumin with hyaluronic acid and chemotherapy agents like HA-CPT/CUR-NPs is more effective than usual chemotherapic procedures against colon-26 cells [77]. Singh et al. reported silica modified curcumin complex conjugated with hyaluronic acid (HA-SiNp-cur) in human colon carcinoma colo205 cells. Their study has shown improvement in cytotoxicity in carcinoma cells of the colon [45]. | |
Pancreatic cancer | Curcumin/gelatin-blended nanofibrous mat [78] | Nanomicelles of HA-SMA-CDF | Kesharwani et al. reported the significant effect of nanomicelles of hyaluronic acid-styrene maleic acid-anti-cancer agent, 3,4-difluorobenzylidene curcumin HA-SMA-CDF in inhibition of proliferation of NF-κB, the cancer-causing cells. Their results suggest HA and Cur nanomicelles have great implications in treating pancreatic cancers [41]. |
Diabetic wound | Curcumin and Hyaluronic formulation reported only for the diabetic wound healing | Hussain et al. fabricated curcumin and resveratrol carrier nanoparticles CUR-REV-CS-NPs functionalized with HA and optimized their physicochemical characteristics, storage stability, thermal stability, and release kinetics for diabetic wound healing that would reduce the frequency of topical application for the management of diabetic wound, improve therapeutic efficacy, increase localized targeting and prolong the residence of curcumin and resveratrol at the target site [28, 82]. | |
Arthritis | Curcumin oral dose [83] | Hyaluronic acid/curcumin (HA/ Cur) nanomicelle | Fan et al. constructed a nanomicelle of HA/Cur for potential therapy of rheumatoid arthritis. The newly found drug showed excellent anti-inflammatory effect in mice experiment. The constructed drug can reduce the expression of related cytokines and VEGF, developing in a targeted inhibition of the inflammatory response [37]. |
Wound healing | By various methods | Cur-HA-SPu | Curcumin with hyaluronic acid pullulan Cur-HA-SPu showed better results in wound healing, through producing no cytotoxicity, rapid cell proliferation, antioxidant, and antibacterial activities [47]. |