Table 2 Application of nasal route for CNS targeting of different drug molecules
From: Cerebral ischemic stroke and different approaches for treatment of stroke
Name of the drug | Applicability | Advantage of nose-to-brain route |
|---|---|---|
Saquinavir messylate nanoemulsion | Antiretroviral acts as a protease inhibitor | Effective CNS targeting with an increase in brain concentration [66] |
Venlafaxine chitosan nanoparticles | Antidepressant by inhibiting serotonin and norepinephrine reuptake inhibitor | Better brain uptake and high drug transport the efficiency of drug [67] |
Olanzapine nanoemulsion | Antipsychotic used to treat schizophrenia | Rapid and greater transport and distribution in the brain [68] |
Insulin-like growth factor-I | In the treatment of focal cerebral ischemic damage | Reduced infarct volume up to 63% with improved neurological functions [69] |
Fas-blocking peptide | Apoptosis inhibitor | Decreased cell death, infarct volume, and enhanced cell recovery [70] |