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Table 1 Individual drugs and excipients and their physical mixtures for compatibility study. The assay results indicated recoveries of drugs only

From: Physicochemical compatibility studies of triclosan and flurbiprofen with excipients of pharmaceutical formulation using binary, ternary, and multi-combination approach

S/No.

Sample

Drug content (% recovery), ± SD, n = 3

% RSD

1

TCS

100.30 ± 1.54

0.60

2

FLB

99.65 ± 2.06

0.12

3

PCL

4

CS

5

KP

6

TCS + FLB

101.49a ± 0.80a & 99.71b ± 1.19b

0.16a & 0.33b

7

PCL + CS + KP

8

TCS + PCL

97.73a ± 2.72a

1.61a

9

TCS + CS

100.27a ± 1.22a

0.56a

10

TCS + KP

101.83a ± 1.55a

0.98a

11

FLB + PCL

97.04b ± 2.18b

1.38b

12

FLB + CS

98.11b ± 4.05b

0.32b

13

FLB + KP

100.01b ± 0.79b

0.64b

14

TCS + FLB + PCL + CS + KP

98.37a ± 3.50a & 98.74b ± 0.76b

1.20a & 0.47b

  1. Triclosan (TCS; a); flurbiprofen (FLB; b); Kolliphor® P188 (KP); chitosan (CS); standard deviation (SD); poly-ε-caprolactone (PCL); relative standard deviation (RSD)