Skip to main content

Table 1 Difference between M1 and M2 macrophages

From: A review on importance of bioactive compounds of medicinal plants in treating idiopathic pulmonary fibrosis (special emphasis on isoquinoline alkaloids)

  M1 macrophages M2 macrophages
Activation Classically activated Alternatively activated
Th cell involved Th1 cells Th2 Cells
Subtypes M2a, M2b and M2c
Stimuli IFN-γ or lipopolysaccharide (LPS) IL-4, IL-10 or IL-13
Antigen presentation Yes No
Proinflammatory cytokines High levels Low Levels
Autophagy Induced Decreased
Nitric oxide production Yes No
Phagocytosis Increases Decreases
Function Protect against bacteria and viruses Wound healing and tissue repair build extracellular matrix