Table 3 90% confidence intervals of LnCmax, LnAUC0–t, and LnAUC0–∞ from the test formulations to the reference formulation
From: Bioequivalence study of different brands of vildagliptin in healthy human subjects
Pharmacokinetic parameter | Geo mean ratio | 90% confidence interval (lower limit-upper limit) | |||
|---|---|---|---|---|---|
Test/reference | |||||
T1/R | T2/R | Test 1 | Test 2 | Bioequivalence range | |
LnCmax | 1.0014 | 1.0003 | 1.0002–1.0026 | 0.9992–1.0013 | 0.80–1.25 |
LnAUC0–t | 0.9992 | 0.9988 | 0.9971–1.0013 | 0.9969–1.0008 | 0.80–1.25 |
LnAUC0–∞ | 0.9994 | 0.9985 | 0.9973–1.0016 | 0.9961–1.0010 | 0.80–1.25 |