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Table 1 Composition of trospium chloride push–pull osmotic pump (PPOP) ER tablet

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

S. no

Ingredients/grade

mg/tablet

(A) Layer I (Pull layer)

Intra-granular

 1

Trospium chloride*

30

 2

Mannitol USP*

62

Binder#

 3

Povidone NF

4

 4

Hydroxy Ethyl Cellulose

3

 5

Isopropyl alcohol NF#

q.s

Extra-granular

 6

Magnesium Stearate NF (Veg grade)

1

Layer I weight (mg)

100

(B) Layer II (Push layer)

Intra-granular

 1

Trospium chloride

30

 2

Polyethylene Oxide NF

250

 3

Iron Oxide Yellow NF

1

Binder#

 4

Povidone NF

11

 5

Isopropyl alcohol NF#

q.s

Extra-granular

 6

Magnesium Stearate NF (Veg grade)

3

Layer II weight (mg)

295

Core tablet weight (mg)

395

  1. *Quantity based on 100% assay
  2. #indicates, in finished product Water, Acetone and Isopropyl alcohol will be available in traces