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Table 1 Composition of trospium chloride push–pull osmotic pump (PPOP) ER tablet

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

S. no Ingredients/grade mg/tablet
(A) Layer I (Pull layer)
Intra-granular
 1 Trospium chloride* 30
 2 Mannitol USP* 62
Binder#
 3 Povidone NF 4
 4 Hydroxy Ethyl Cellulose 3
 5 Isopropyl alcohol NF# q.s
Extra-granular
 6 Magnesium Stearate NF (Veg grade) 1
Layer I weight (mg) 100
(B) Layer II (Push layer)
Intra-granular
 1 Trospium chloride 30
 2 Polyethylene Oxide NF 250
 3 Iron Oxide Yellow NF 1
Binder#
 4 Povidone NF 11
 5 Isopropyl alcohol NF# q.s
Extra-granular
 6 Magnesium Stearate NF (Veg grade) 3
Layer II weight (mg) 295
Core tablet weight (mg) 395
  1. *Quantity based on 100% assay
  2. #indicates, in finished product Water, Acetone and Isopropyl alcohol will be available in traces