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Table 12 Pharmacokinetic parameters summary of trospium chloride osmotic tablets vs Sanctura XR® capsules

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Product Trospium chloride ER tablets 60 mg (Osmotic) Sanctura XR® capsules 60 mg (Extended Release)
Analyte Trospium chloride (ng/mL) measured in dogs Trospium chloride (ng/mL) measured in dogs
Parameter Single dose (0–24 h) Single dose (0–24 h)
Cmax (µg/mL) 5.077 (0.754) 5.965 (0.888)
Tmax (h) 3.000 (0.000) 3.000 (0.000)
AUC (µg h/mL) 32.632 (4.096) 32.911 (3.076)
T1/2 (h) 19.523 (7.282) 3.504 (0.247)