Table 12 Pharmacokinetic parameters summary of trospium chloride osmotic tablets vs Sanctura XR® capsules
Product | Trospium chloride ER tablets 60 mg (Osmotic) | Sanctura XR® capsules 60 mg (Extended Release) |
|---|---|---|
Analyte | Trospium chloride (ng/mL) measured in dogs | Trospium chloride (ng/mL) measured in dogs |
Parameter | Single dose (0–24 h) | Single dose (0–24 h) |
Cmax (µg/mL) | 5.077 (0.754) | 5.965 (0.888) |
Tmax (h) | 3.000 (0.000) | 3.000 (0.000) |
AUC (µg h/mL) | 32.632 (4.096) | 32.911 (3.076) |
T1/2 (h) | 19.523 (7.282) | 3.504 (0.247) |