Table 2 Coating composition for trospium chloride push–pull osmotic pump (PPOP) ER tablet
Seal coating composition | ER coating composition | |||||
|---|---|---|---|---|---|---|
Sr. no | Ingredients | % w/w | mg/tablet | Ingredients | % w/w | mg/tablet |
1 | Core tablet | – | 395 | Seal coated tablet | – | 407 |
2 | Hydroxypropyl Cellulose NF | 83.33 | 10 | Cellulose Acetate | 94.05 | 42.7 |
3 | Polyethylene glycol 400 NF | 16.67 | 2 | Polyethylene glycol 3350 NF | 5.95 | 2.7 |
4 | Isopropyl alcohol NF | – | q.s | Acetone NF (99% part) | – | q.s |
Solid content of coating solution (%w/w) | 5 | Purified water USP (10% part) | – | q.s | ||
Target Weight Gain (%w/w) | 3 | Solid content (%w/w) | 3 | |||
Seal coated tablet weight (mg) | 407 | Target Weight Gain (%w/w) | 11 | |||
– | – | Seal coated + ER coated tablet weight (mg) | 452.4 | |||