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Table 2 Coating composition for trospium chloride push–pull osmotic pump (PPOP) ER tablet

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Seal coating composition ER coating composition
Sr. no Ingredients % w/w mg/tablet Ingredients % w/w mg/tablet
1 Core tablet 395 Seal coated tablet 407
2 Hydroxypropyl Cellulose NF 83.33 10 Cellulose Acetate 94.05 42.7
3 Polyethylene glycol 400 NF 16.67 2 Polyethylene glycol 3350 NF 5.95 2.7
4 Isopropyl alcohol NF q.s Acetone NF (99% part) q.s
Solid content of coating solution (%w/w) 5 Purified water USP (10% part) q.s
Target Weight Gain (%w/w) 3 Solid content (%w/w) 3
Seal coated tablet weight (mg) 407 Target Weight Gain (%w/w) 11
Seal coated + ER coated tablet weight (mg) 452.4
  1. Bold indicates the total weight after seal coating and Extended Release (ER) coating