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Table 7 Preformulation characteristics of tablet blend of all experimental batches

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Batch

Angle of repose (°)

Bulk density (g/cm3)

Tapped density (g/cm3)

Compressibility Carr’s index

Hausner’s ratio

TSP1

28.61 ± 0.12

0.492 ± 0.02

0.579 ± 0.02

15.25 ± 0.01

1.18 ± 0.09

TSP2

28.24 ± 0.11

0.495 ± 0.01

0.582 ± 0.01

15.21 ± 0.03

1.19 ± 0.07

TSP3

28.76 ± 0.09

0.488 ± 0.02

0.575 ± 0.02

15.18 ± 0.05

1.17 ± 0.04

TSP4

28.85 ± 0.08

0.491 ± 0.02

0.581 ± 0.02

15.28 ± 0.1

1.16 ± 0.04

TSP5

28.58 ± 0.13

0.493 ± 0.01

0.576 ± 0.01

15.23 ± 0.02

1.18 ± 0.03

TSP6

28.45 ± 0.14

0.489 ± 0.03

0.585 ± 0.02

15.18 ± 0.09

1.19 ± 0.05

TSP7

28.39 ± 0.11

0.491 ± 0.02

0.574 ± 0.02

15.21 ± 0.03

1.17 ± 0.06

TSP8

28.67 ± 0.15

0.486 ± 0.01

0.579 ± 0.01

15.26 ± 0.04

1.18 ± 0.01

TSP9

28.51 ± 0.12

0.494 ± 0.02

0.580 ± 0.02

15.22 ± 0.02

1.19 ± 0.04

TSP10

28.73 ± 0.11

0.491 ± 0.01

0.578 ± 0.02

15.28 ± 0.03

1.18 ± 0.10

TSP11

28.43 ± 0.15

0.486 ± 0.01

0.586 ± 0.02

15.21 ± 0.1

1.17 ± 0.09

TSP12

28.58 ± 0.15

0.488 ± 0.02

0.575 ± 0.01

15.26 ± 0.04

1.16 ± 0.03

TSP13

28.34 ± 0.09

0.490 ± 0.02

0.571 ± 0.01

15.22 ± 0.05

1.18 ± 0.05

TSP14

28.57 ± 0.11

0.493 ± 0.02

0.576 ± 0.01

15.18 ± 0.07

1.18 ± 0.09

TSP15

28.69 ± 0.10

0.499 ± 0.03

0.578 ± 0.01

15.21 ± 0.1

1.2 ± 0.10

TSP16

28.24 ± 0.07

0.487 ± 0.02

0.584 ± 0.02

15.23 ± 0.06

1.18 ± 0.11

TSP17

28.56 ± 0.17

0.491 ± 0.02

0.572 ± 0.02

15.16 ± 0.08

1.19 ± 0.03

TSP18

28.49 ± 0.14

0.493 ± 0.01

0.577 ± 0.01

15.22 ± 0.01

1.17 ± 0.04

TSP19

28.53 ± 0.12

0.490 ± 0.02

0.579 ± 0.01

15.25 ± 0.06

1.20 ± 0.03

TSP20

28.58 ± 0.11

0.489 ± 0.02

0.578 ± 0.02

15.18 ± 0.09

1.18 ± 0.04

  1. Values are expressed as mean ± S.E.M; n = 3