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Table 7 Preformulation characteristics of tablet blend of all experimental batches

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Batch Angle of repose (°) Bulk density (g/cm3) Tapped density (g/cm3) Compressibility Carr’s index Hausner’s ratio
TSP1 28.61 ± 0.12 0.492 ± 0.02 0.579 ± 0.02 15.25 ± 0.01 1.18 ± 0.09
TSP2 28.24 ± 0.11 0.495 ± 0.01 0.582 ± 0.01 15.21 ± 0.03 1.19 ± 0.07
TSP3 28.76 ± 0.09 0.488 ± 0.02 0.575 ± 0.02 15.18 ± 0.05 1.17 ± 0.04
TSP4 28.85 ± 0.08 0.491 ± 0.02 0.581 ± 0.02 15.28 ± 0.1 1.16 ± 0.04
TSP5 28.58 ± 0.13 0.493 ± 0.01 0.576 ± 0.01 15.23 ± 0.02 1.18 ± 0.03
TSP6 28.45 ± 0.14 0.489 ± 0.03 0.585 ± 0.02 15.18 ± 0.09 1.19 ± 0.05
TSP7 28.39 ± 0.11 0.491 ± 0.02 0.574 ± 0.02 15.21 ± 0.03 1.17 ± 0.06
TSP8 28.67 ± 0.15 0.486 ± 0.01 0.579 ± 0.01 15.26 ± 0.04 1.18 ± 0.01
TSP9 28.51 ± 0.12 0.494 ± 0.02 0.580 ± 0.02 15.22 ± 0.02 1.19 ± 0.04
TSP10 28.73 ± 0.11 0.491 ± 0.01 0.578 ± 0.02 15.28 ± 0.03 1.18 ± 0.10
TSP11 28.43 ± 0.15 0.486 ± 0.01 0.586 ± 0.02 15.21 ± 0.1 1.17 ± 0.09
TSP12 28.58 ± 0.15 0.488 ± 0.02 0.575 ± 0.01 15.26 ± 0.04 1.16 ± 0.03
TSP13 28.34 ± 0.09 0.490 ± 0.02 0.571 ± 0.01 15.22 ± 0.05 1.18 ± 0.05
TSP14 28.57 ± 0.11 0.493 ± 0.02 0.576 ± 0.01 15.18 ± 0.07 1.18 ± 0.09
TSP15 28.69 ± 0.10 0.499 ± 0.03 0.578 ± 0.01 15.21 ± 0.1 1.2 ± 0.10
TSP16 28.24 ± 0.07 0.487 ± 0.02 0.584 ± 0.02 15.23 ± 0.06 1.18 ± 0.11
TSP17 28.56 ± 0.17 0.491 ± 0.02 0.572 ± 0.02 15.16 ± 0.08 1.19 ± 0.03
TSP18 28.49 ± 0.14 0.493 ± 0.01 0.577 ± 0.01 15.22 ± 0.01 1.17 ± 0.04
TSP19 28.53 ± 0.12 0.490 ± 0.02 0.579 ± 0.01 15.25 ± 0.06 1.20 ± 0.03
TSP20 28.58 ± 0.11 0.489 ± 0.02 0.578 ± 0.02 15.18 ± 0.09 1.18 ± 0.04
  1. Values are expressed as mean ± S.E.M; n = 3