Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Future Journal of Pharmaceutical Sciences

Table 9 (a) Release kinetics of DOE batches TSP-1 to TSP-10, (b) release kinetics of DOE batches TSP-11 to TSP-20

Trials	Unit	TSP-1	TSP-2	TSP-3	TSP-4	TSP-5	TSP-6	TSP-7	TSP-8	TSP-9	TSP-10
(a)
Zero order	K0	5.298	5.277	4.468	5.303	5.730	6.260	4.693	5.489	5.314	5.000
Zero order	R2	0.921	0.918	0.986	0.987	0.933	0.551	0.996	0.849	0.974	0.984
First order	K	0.107	0.107	0.070	0.097	0.122	0.208	0.077	0.122	0.101	0.090
First order	R2	0.984	0.986	0.902	0.924	0.957	0.981	0.931	0.983	0.958	0.966
Korsmeyer Peppas	N	0.642	0.640	1.173	0.931	0.720	0.360	1.001	0.580	0.802	0.821
	KKP	14.068	14.075	2.774	6.409	12.340	35.520	4.669	17.262	9.142	8.163
	R2	0.998	0.996	0.994	0.989	0.976	0.990	0.996	0.971	0.992	0.999
Higuchi	KH	20.348	20.272	16.496	19.881	21.860	24.778	17.533	21.229	20.128	18.913
Higuchi	R2	0.979	0.978	0.819	0.885	0.937	0.958	0.874	0.965	0.929	0.930
Hixon–Crowell	KHc	0.029	0.029	0.020	0.027	0.033	0.054	0.022	0.033	0.028	0.025
Hixon–Crowell	R2	0.991	0.992	0.934	0.959	0.984	0.961	0.960	0.982	0.984	0.987

Trials	Unit	TSP-11	TSP-12	TSP-13	TSP-14	TSP-15	TSP-16	TSP-17	TSP-18	TSP-19	TSP-20
(b)
Zero order	K0	4.832	4.272	5.284	5.096	5.474	4.810	6.259	5.648	5.794	4.969
Zero order	R2	0.986	0.984	0.916	0.960	0.878	0.988	0.401	0.872	0.936	0.987
First order	K	0.080	0.065	0.107	0.096	0.118	0.083	0.237	0.127	0.122	0.084
First order	R2	0.905	0.901	0.986	0.978	0.986	0.950	0.984	0.980	0.934	0.905
Korsmeyer Peppas	n	1.074	1.216	0.632	0.735	0.577	0.898	0.304	0.613	0.762	1.055
	KKP	3.938	2.356	14.399	10.522	17.307	6.371	41.223	16.245	11.103	4.268
	R2	0.988	0.996	0.999	0.996	0.999	0.992	0.988	0.971	0.965	0.988
Higuchi	KH	17.943	15.738	20.311	19.414	21.151	18.088	24.960	21.776	22.014	18.468
Higuchi	R2	0.842	0.810	0.982	0.954	0.993	0.900	0.916	0.958	0.913	0.846
Hixon–Crowell	KHc	0.023	0.019	0.029	0.027	0.032	0.023	0.061	0.034	0.033	0.024
Hixon–Crowell	R2	0.938	0.932	0.992	0.994	0.987	0.974	0.954	0.989	0.966	0.940