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Table 2 Thrombolytic activity of the investigated extracts of M. dispermus leaves and stem barks

From: Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Group

Mean ± SEM % of clot lysis

Control

3.71 ± 0.44

Standard (streptokinase)

64.72 ± 1.88***

MDML (10 mg/ml)

27.36 ± 3.83**

MDML (8 mg/ml)

25.01 ± 3.97

MDML (6 mg/ml)

23.44 ± 3.32**

MDML (3 mg/ml)

9.38 ± 1.63

MDML (1.5 mg/ml)

7.81 ± 0.88

MDHL (10 mg/ml)

37.05 ± 2.69***

MDHL (8 mg/ml)

36.27 ± 1.70***

MDHL (6 mg/ml)

27.89 ± 2.18***

MDHL (3 mg/ml)

22.89 ± 1.79***

MDHL(1.5 mg/ml)

12.62 ± 1.89

MDTL (10 mg/ml)

15.95 ± 1.96*

MDTL(8 mg/ml)

13.62 ± 1.64*

MDTL (6 mg/ml)

12.28 ± 1.46*

MDTL (3 mg/ml)

10.49 ± 1.04*

MDTL (1.5 mg/ml)

9.89 ± 0.96*

MDCL(10 mg/ml)

29.81 ± 1.71***

MDCL (8 mg/ml)

21.17 ± 1.92**

MDCL (6 mg/ml)

15.61 ± 1.45**

MDCL (3 mg/ml)

12.32 ± 0.89***

MDCL (1.5 mg/ml)

9.52 ± 1.03*

MDEL (10 mg/ml)

16.15 ± 1.36**

MDEL (8 mg/ml)

8.49 ± 1.41

MDEL (6 mg/ml)

7.85 ± 0.73

MDEL (3 mg/ml)

6.26 ± 0.93

MDEL (1.5 mg/ml)

3.52 ± 0.90

MDMS (10 mg/ml)

42.21 ± 1.84***

MDMS (8 mg/ml)

29.27 ± 2.71**

MDMS (6 mg/ml)

26.89 ± 2.73**

MDMS (3 mg/ml)

18.40 ± 1.66**

MDMS (1.5 mg/ml)

17.89 ± 2.36*

  1. The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett’s test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks