Skip to main content
Future Journal of Pharmaceutical Sciences

Table 4 Analgesic effect of the investigated extracts of M. dispermus leaves and stem barks on acetic acid-induced writhing test

From: Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Groups

No. of writhing

Inhibition of writhing (%)

Control

48.40 ± 1.44

–

Diclofenac Sodium (50 mg/kg)

4.20 ± 0.86***

91.32

MDML (200 mg/kg)

11.80 ± 1.43***

75.62

MDML (400 mg/kg)

7.60 ± 1.03***

84.30

MDHL (200 mg/kg)

19.00 ± 1.22***

60.74

MDHL (400 mg/kg)

11.20 ± 0.86***

76.86

MDTL (200 mg/kg)

18.00 ± 1.38***

62.81

MDTL (400 mg/kg)

10.00 ± 1.64***

79.34

MDCL (200 mg/kg)

14.20 ± 1.39***

70.66

MDCL (400 mg/kg)

8.60 ± 0.68***

82.23

MDEL (200 mg/kg)

11.40 ± 1.72***

76.45

MDEL (400 mg/kg)

9.60 ± 0.93***

80.17

MDAL (200 mg/kg)

22.20 ± 2.82***

54.13

MDAL (400 mg/kg)

13.20 ± 2.52***

72.73

MDMS (200 mg/kg)

14.40 ± 1.63***

70.25

MDMS (400 mg/kg)

11.20 ± 1.24***

76.86

  1. The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett's test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDAL = Aqueous fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks
Back to article page