Skip to main content

Table 4 Analgesic effect of the investigated extracts of M. dispermus leaves and stem barks on acetic acid-induced writhing test

From: Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Groups No. of writhing Inhibition of writhing (%)
Control 48.40 ± 1.44
Diclofenac Sodium (50 mg/kg) 4.20 ± 0.86*** 91.32
MDML (200 mg/kg) 11.80 ± 1.43*** 75.62
MDML (400 mg/kg) 7.60 ± 1.03*** 84.30
MDHL (200 mg/kg) 19.00 ± 1.22*** 60.74
MDHL (400 mg/kg) 11.20 ± 0.86*** 76.86
MDTL (200 mg/kg) 18.00 ± 1.38*** 62.81
MDTL (400 mg/kg) 10.00 ± 1.64*** 79.34
MDCL (200 mg/kg) 14.20 ± 1.39*** 70.66
MDCL (400 mg/kg) 8.60 ± 0.68*** 82.23
MDEL (200 mg/kg) 11.40 ± 1.72*** 76.45
MDEL (400 mg/kg) 9.60 ± 0.93*** 80.17
MDAL (200 mg/kg) 22.20 ± 2.82*** 54.13
MDAL (400 mg/kg) 13.20 ± 2.52*** 72.73
MDMS (200 mg/kg) 14.40 ± 1.63*** 70.25
MDMS (400 mg/kg) 11.20 ± 1.24*** 76.86
  1. The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett's test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDAL = Aqueous fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks