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Table 8 Antipyretic effect of the investigated extracts of M. dispermus leaves and stem barks on brewer’s yeast-induced pyrexia test

From: Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Group Normal rectal temperature (°F) After yeast administration Rectal temperature after drug administration (°F)
1 h 2 h 3 h 4 h
Control 97.34 ± 0.7 100.96 ± 0.32 101.72 ± 0.37 102.40 ± 0.30 102.42 ± 0.34 102.12 ± 0.35
Paracetamol (150 mg/kg) 96.82 ± 0.62 100.48 ± 0.27 98.08 ± 0.32*** 97.48 ± 0.34*** 97.12 ± 0.47*** 96.82 ± 0.53***
MDML (200 mg/kg) 97.02 ± 0.66 99.82 ± 0.10 98.96 ± 0.28*** 98.10 ± 0.38*** 97.62 ± 0.41*** 97.84 ± 0.40***
MDML (400 mg/kg) 98.50 ± 0.42 100.06 ± 0.42 99.54 ± 0.19*** 98.96 ± 0.28*** 98.68 ± 0.31*** 98.88 ± 0.26***
MDHL (200 mg/kg) 97.22 ± 0.71 100.76 ± 0.42 100.30 ± 0.49*** 99.90 ± 0.47*** 98.90 ± 0.38*** 98.30 ± 0.33***
MDHL (400 mg/kg) 98.06 ± 0.30 100.34 ± 0.42 99.66 ± 0.48*** 98.76 ± 0.41*** 98.30 ± 0.30*** 98.16 ± 0.33***
MDTL (200 mg/kg) 98.60 ± 0.20 101.06 ± 0.19 101.48 ± 0.15 100.64 ± 0.14** 99.14 ± 0.34*** 99.30 ± 0.32***
MDTL (400 mg/kg) 97.58 ± 0.47 99.98 ± 0.13 100.88 ± 0.35 99.24 ± 0.35*** 98.08 ± 0.29*** 97.62 ± 0.34***
MDCL (200 mg/kg) 97.88 ± 0.48 101.28 ± 0.21 101.42 ± 0.24 101.62 ± 0.26 99.58 ± 0.27*** 98.74 ± 0.19***
MDCL (400 mg/kg) 97.10 ± 0.37 100.86 ± 0.27 101.08 ± 0.30 101.48 ± 0.40 98.80 ± 0.28*** 97.82 ± 0.10***
MDEL (200 mg/kg) 97.02 ± 0.55 100.92 ± 0.37 99.80 ± 0.28** 99.18 ± 0.26*** 98.44 ± 0.18*** 98.16 ± 0.15***
MDEL (400 mg/kg) 97.32 ± 0.30 100.46 ± 0.18 99.32 ± 0.13*** 98.50 ± 0.29*** 97.64 ± 0.37*** 97.42 ± 0.28***
MDAL (200 mg/kg) 96.68 ± 0.33 100.52 ± 0.29 100.66 ± 0.32 101.16 ± 0.3 98.88 ± 0.38*** 98.74 ± 0.37***
MDAL (400 mg/kg) 97.38 ± 0.31 101.28 ± 0.42 101.54 ± 0.43 100.42 ± 0.37** 98.80 ± 0.34*** 98.34 ± 0.20***
MDMS (200 mg/kg) 97.66 ± 0.65 100.08 ± 0.15 101.00 ± 0.28 99.92 ± 0.23*** 98.62 ± 0.44*** 98.72 ± 0.40***
MDMS (400 mg/kg) 96.64 ± 0.40 99.48 ± 0.44 100.32 ± 0.25* 98.90 ± 0.54*** 97.30 ± 0.29*** 97.10 ± 0.32***
  1. The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett's test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDAL = Aqueous fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks