Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Afrin, Syeda Rubaiya; Islam, Mohammad Rashedul; Khanam, Bibi Humayra; Proma, Nawreen Monir; Didari, Sayeda Saima; Jannat, Sarah Waddun; Hossain, Mohammed Kamrul

doi:10.1186/s43094-021-00313-4

Future Journal of Pharmaceutical Sciences

Table 8 Antipyretic effect of the investigated extracts of M. dispermus leaves and stem barks on brewer’s yeast-induced pyrexia test

From: Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Group	Normal rectal temperature (°F)	After yeast administration	Rectal temperature after drug administration (°F)
Group	Normal rectal temperature (°F)	After yeast administration	1 h	2 h	3 h	4 h
Control	97.34 ± 0.7	100.96 ± 0.32	101.72 ± 0.37	102.40 ± 0.30	102.42 ± 0.34	102.12 ± 0.35
Paracetamol (150 mg/kg)	96.82 ± 0.62	100.48 ± 0.27	98.08 ± 0.32***	97.48 ± 0.34***	97.12 ± 0.47***	96.82 ± 0.53***
MDML (200 mg/kg)	97.02 ± 0.66	99.82 ± 0.10	98.96 ± 0.28***	98.10 ± 0.38***	97.62 ± 0.41***	97.84 ± 0.40***
MDML (400 mg/kg)	98.50 ± 0.42	100.06 ± 0.42	99.54 ± 0.19***	98.96 ± 0.28***	98.68 ± 0.31***	98.88 ± 0.26***
MDHL (200 mg/kg)	97.22 ± 0.71	100.76 ± 0.42	100.30 ± 0.49***	99.90 ± 0.47***	98.90 ± 0.38***	98.30 ± 0.33***
MDHL (400 mg/kg)	98.06 ± 0.30	100.34 ± 0.42	99.66 ± 0.48***	98.76 ± 0.41***	98.30 ± 0.30***	98.16 ± 0.33***
MDTL (200 mg/kg)	98.60 ± 0.20	101.06 ± 0.19	101.48 ± 0.15	100.64 ± 0.14**	99.14 ± 0.34***	99.30 ± 0.32***
MDTL (400 mg/kg)	97.58 ± 0.47	99.98 ± 0.13	100.88 ± 0.35	99.24 ± 0.35***	98.08 ± 0.29***	97.62 ± 0.34***
MDCL (200 mg/kg)	97.88 ± 0.48	101.28 ± 0.21	101.42 ± 0.24	101.62 ± 0.26	99.58 ± 0.27***	98.74 ± 0.19***
MDCL (400 mg/kg)	97.10 ± 0.37	100.86 ± 0.27	101.08 ± 0.30	101.48 ± 0.40	98.80 ± 0.28***	97.82 ± 0.10***
MDEL (200 mg/kg)	97.02 ± 0.55	100.92 ± 0.37	99.80 ± 0.28**	99.18 ± 0.26***	98.44 ± 0.18***	98.16 ± 0.15***
MDEL (400 mg/kg)	97.32 ± 0.30	100.46 ± 0.18	99.32 ± 0.13***	98.50 ± 0.29***	97.64 ± 0.37***	97.42 ± 0.28***
MDAL (200 mg/kg)	96.68 ± 0.33	100.52 ± 0.29	100.66 ± 0.32	101.16 ± 0.3	98.88 ± 0.38***	98.74 ± 0.37***
MDAL (400 mg/kg)	97.38 ± 0.31	101.28 ± 0.42	101.54 ± 0.43	100.42 ± 0.37**	98.80 ± 0.34***	98.34 ± 0.20***
MDMS (200 mg/kg)	97.66 ± 0.65	100.08 ± 0.15	101.00 ± 0.28	99.92 ± 0.23***	98.62 ± 0.44***	98.72 ± 0.40***
MDMS (400 mg/kg)	96.64 ± 0.40	99.48 ± 0.44	100.32 ± 0.25*	98.90 ± 0.54***	97.30 ± 0.29***	97.10 ± 0.32***

The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett's test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDAL = Aqueous fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks

Back to article page