Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Future Journal of Pharmaceutical Sciences

Table 9 Percent decrease in rectal temperature of all test samples of M. dispermus leaves and stem barks on brewer’s yeast-induced pyrexia test

Group	Percent decrease in rectal temperature (%) after drug treatment
Group	1 h	2 h	3 h	4 h
Paracetamol (150 mg/kg)	65.57	81.97	91.8	100
MDML (200 mg/kg)	30.71	61.43	78.57	70.71
MDML (400 mg/kg)	33.33	70.51	88.46	75.64
MDHL (200 mg/kg)	12.99	24.29	52.54	69.49
MDHL (400 mg/kg)	29.82	69.3	89.47	95.61
MDTL (200 mg/kg)	–	17.07	78.05	71.54
MDTL (400 mg/kg)	–	30.83	79.17	98.33
MDCL (200 mg/kg)	–	–	50.00	74.71
MDCL (400 mg/kg)	–	–	54.79	80.85
MDEL (200 mg/kg)	28.72	44.62	63.59	70.77
MDEL (400 mg/kg)	36.31	62.42	89.81	96.82
MDAL (200 mg/kg)	–	–	42.71	46.35
MDAL (400 mg/kg)	–	22.05	63.59	75.38
MDMS (200 mg/kg)	–	6.61	60.33	56.2
MDMS (400 mg/kg)	–	20.42	76.76	83.8

The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett's test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDAL = Aqueous fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks, ‘–’ indicates the reduction of temperature didn’t occur at a time interval