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Table 9 Percent decrease in rectal temperature of all test samples of M. dispermus leaves and stem barks on brewer’s yeast-induced pyrexia test

From: Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Group

Percent decrease in rectal temperature (%) after drug treatment

1 h

2 h

3 h

4 h

Paracetamol (150 mg/kg)

65.57

81.97

91.8

100

MDML (200 mg/kg)

30.71

61.43

78.57

70.71

MDML (400 mg/kg)

33.33

70.51

88.46

75.64

MDHL (200 mg/kg)

12.99

24.29

52.54

69.49

MDHL (400 mg/kg)

29.82

69.3

89.47

95.61

MDTL (200 mg/kg)

17.07

78.05

71.54

MDTL (400 mg/kg)

30.83

79.17

98.33

MDCL (200 mg/kg)

50.00

74.71

MDCL (400 mg/kg)

54.79

80.85

MDEL (200 mg/kg)

28.72

44.62

63.59

70.77

MDEL (400 mg/kg)

36.31

62.42

89.81

96.82

MDAL (200 mg/kg)

42.71

46.35

MDAL (400 mg/kg)

22.05

63.59

75.38

MDMS (200 mg/kg)

6.61

60.33

56.2

MDMS (400 mg/kg)

20.42

76.76

83.8

  1. The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett's test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDAL = Aqueous fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks, ‘–’ indicates the reduction of temperature didn’t occur at a time interval