Pharmacognostical evaluation and anti-convulsant property of Annona reticulata Linn. (Annonaceae) root

Future Journal of Pharmaceutical Sciences

Table 4 Effect of ethanol extract of A. reticulata root on PTZ induced convulsion in mice

Groups	Onset (s)	Straub’s tail (s)	Convulsion (s)	Recovery (s)
Control (0.1% Sodium CMC)	212.16 ± 8.63	114.83 ± 8.93	55.66 ± 2.53	926 ± 49.62
Standard (diazepam (5 mg/kg) + PTZ	Absent	–	–	–
100 mg/kg + PTZ	234.16 ± 11.05	58.66 ± 25.46^c	23 ± 4.12^a	852.5 ± 51.42
200 mg/kg + PTZ	237.33 ± 5.47	24.66 ± 8.74^b	19.16 ± 2.66^a	522.66 ± 28.90^a,i
400 mg/kg + PTZ	280.16 ± 9.81^a,^e,h	1.5 ± 0.50^a,^f	2.3 ± 0.21^a,^d,g	377.33 ± 19.88^a,d

PTZ pentylenetetrazole
Values are expressed as Mean ± SEM; n = 6. One-way analysis of variance (ANOVA): p value found to be < 0.0001, considered extremely significant. Tukey–Kramer multiple comparisons test
^ap < 0.001 in comparison with control
^bp < 0.01 in comparison with control
^cp < 0.05 in comparison with control
^dp < 0.001 in comparison with low dose
^ep < 0.01 in comparison with low dose
^fp < 0.05 in comparison with low dose
^gp < 0.01 in comparison with medium dose
^hp < 0.05 in comparison with medium dose
ⁱp < 0.001 in comparison with low dose