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Table 3 Utility of nanofibers in transdermal delivery of anticancer therapeutic agents

From: Nanofiber as a novel vehicle for transdermal delivery of therapeutic agents: challenges and opportunities

S. No Drug Polymer Drug loading (%)/diameter (nm) Sophisticated techniques used for characterization/animal model used Key findings Ref
1 Gold nanoparticles (AuNPs) and curcumin Polyvinyl alcohol (PVA), poly caprolactone (PCL) 95.60 (for PCL + curcumin nanofibers)/300 (PVA + gold nanoparticles nanofibers), 600 (for PCL + curcumin nanofibers) SEM, FT-IR, DNA Fragmentation Assay, Fluorescence Microscopy/not given Gold nanoparticles loaded nanofibers showed better in-vitro cytotoxicity against 3T3 fibroblast and A431 skin cancer cells compared to curcumin loaded nanofibers and marketed antineoplastic agents [76]
2 Doxorubicin Poly(lactic co-glycolic acid), poly-caprolactone, gelatin Not given/170 SEM, Hematoxylin and eosin (HE) staining, Immuno Histochemistry/female C57BL/6 mice Developed nanofibers showed extended in-vitro release of doxorubicin for 360 h followed by a significant reduction in tumor volume and side effects of drug compared to marketed injection of doxorubicin in experimental animals [77]
3 5-fluorouracil Polyvinyl alcohol, chitosan 78.90 ± 3.1/162.7 SEM, Fluorescence Microscopy/not given Developed nanofibers were capable to sustain the release of drug and reduce in-vitro tumor cell viability up to 10% after 48 h of application [78]
4 Curcumin Poly(dl-lactic-co-glycolic) acid 81.1 ± 0.97/160 ± 10 SEM, FT-IR, XRD/not given Nanofibers showed in-vitro release of curcumin following non- Fickian diffusion mechanism and excellent in-vitro cytotoxic effect against A431 cells [79]
5 Titanium oxide nanoparticles mixed with cobalt ferrite, Doxorubicin hydro chloride Chitosan 96.5 ± 1/110 SEM, XRD, FESEM/not given Doxorubicin hydrochloride loaded magnetic nanofibers showed its quick release in the acidic medium after application of an external magnetic field and high anticancer activity against B16F10 cells in-vitro under similar condition [80]