Table 4 Carcinogenicity and mutagenicity of AMES test and hERG inhibition prediction for the ART-THY hybrids, parental and control compounds
Compound name | Mutagenicity (Ames test) | Carcinogenicity | hERG inhibition | |
|---|---|---|---|---|
Mouse | Rat | |||
Parental ligands | ||||
ART | Mutagen | Negative | Positive | Low risk |
ARA | Non-mutagen | Negative | Positive | Low risk |
THY | Mutagen | Positive | Positive | Low risk |
Artemisinin–thymoquinone hybrids | ||||
T1 | Non-mutagen | Negative | Positive | Low risk |
T2 | Non-mutagen | Negative | Positive | Low risk |
T3 | Non-mutagen | Negative | Positive | Low risk |
T4 | Non-mutagen | Negative | Positive | Low risk |
T5 | Non-mutagen | Negative | Positive | Low risk |
T6 | Non-mutagen | Negative | Negative | Low risk |
T7 | Non-mutagen | Negative | Negative | Low risk |
Control-ligands | ||||
ANK | Mutagen | Positive | Negative | Ambiguous |
AZT | Non-mutagen | Negative | Negative | Ambiguous |
BRT | Mutagen | Negative | Negative | Medium risk |
CLQ | Mutagen | Negative | Positive | Medium risk |
RDS | Non-mutagen | Negative | Negative | Ambiguous |