Table 2 Experimental formulation (Runs) and observed results from response surface design
From: Response surface method for optimization of prepared satranidazole powder layered pellets
Batch no | Batch code a | Independent variables | Dependent variables | ||||
|---|---|---|---|---|---|---|---|
X1: Ratio of coating mixture (Locust bean gum: Xanthan gum & Locust bean gum: Chitosan gum) (%) | X2: Coating level (%) | Y1: Drug release at 2 h (%) | Y2: Drug release at 6 h (%) | Y3: Drug release difference in presence & absence of colonic enzyme at 10 h (%) | Y4: Mean dissolution time (MDT) | ||
1(F1) | LX | 50 | 20 | 1.124 | 17.254 | 18.872 | 9.016 |
2(F2) | LX | 50 | 10 | 1.441 | 20.761 | 40.801 | 8.706 |
3(F3) | LX | 33.3 | 30 | 0.086 | 3.784 | 3.896 | 10.508 |
4(F4) | LX | 33.3 | 10 | 1.989 | 11.908 | 30.392 | 7.471 |
5(F5) | LX | 66.7 | 10 | 1.124 | 20.011 | 68.396 | 8.601 |
6(F6) | LX | 66.7 | 30 | 0.547 | 12.096 | 9.146 | 9.669 |
7(F7) | LX | 50 | 30 | 0.001 | 0.0281 | 25.936 | 7.471 |
8(F8) | LX | 33.3 | 20 | 1.960 | 6.655 | 8.409 | 9.784 |
9(F9) | LX | 66.7 | 20 | 0.720 | 10.584 | 25.308 | 9.593 |
10(F10) | LC | 50 | 20 | 0.324 | 5.616 | 15.227 | 10.360 |
11(F11) | LC | 33.3 | 20 | 1.103 | 24.107 | 5.560 | 9.048 |
12(F12) | LC | 66.7 | 20 | 0.121 | 4 | 14.935 | 7.627 |
13(F13) | LC | 50 | 10 | 2.407 | 16.234 | 11.952 | 9.675 |
14(F14) | LC | 50 | 30 | 0.426 | 4.897 | 14.285 | 10.342 |
15(F15) | LC | 33.3 | 10 | 1.038 | 8.001 | 11.908 | 9.298 |
16(F16) | LC | 33.3 | 30 | 0.037 | 0.500 | 6.957 | 10.032 |
17(F17) | LC | 66.7 | 10 | 2.998 | 39.835 | 40.412 | 6.437 |
18(F18) | LC | 66.7 | 30 | 0.278 | 12.022 | 12.745 | 9.424 |