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Table 2 Experimental formulation (Runs) and observed results from response surface design

From: Response surface method for optimization of prepared satranidazole powder layered pellets

Batch no Batch code a Independent variables Dependent variables
X1: Ratio of coating mixture (Locust bean gum: Xanthan gum & Locust bean gum: Chitosan gum) (%) X2: Coating level (%) Y1: Drug release at 2 h (%) Y2: Drug release at 6 h (%) Y3: Drug release difference in presence & absence of colonic enzyme at 10 h (%) Y4: Mean dissolution time (MDT)
1(F1) LX 50 20 1.124 17.254 18.872 9.016
2(F2) LX 50 10 1.441 20.761 40.801 8.706
3(F3) LX 33.3 30 0.086 3.784 3.896 10.508
4(F4) LX 33.3 10 1.989 11.908 30.392 7.471
5(F5) LX 66.7 10 1.124 20.011 68.396 8.601
6(F6) LX 66.7 30 0.547 12.096 9.146 9.669
7(F7) LX 50 30 0.001 0.0281 25.936 7.471
8(F8) LX 33.3 20 1.960 6.655 8.409 9.784
9(F9) LX 66.7 20 0.720 10.584 25.308 9.593
10(F10) LC 50 20 0.324 5.616 15.227 10.360
11(F11) LC 33.3 20 1.103 24.107 5.560 9.048
12(F12) LC 66.7 20 0.121 4 14.935 7.627
13(F13) LC 50 10 2.407 16.234 11.952 9.675
14(F14) LC 50 30 0.426 4.897 14.285 10.342
15(F15) LC 33.3 10 1.038 8.001 11.908 9.298
16(F16) LC 33.3 30 0.037 0.500 6.957 10.032
17(F17) LC 66.7 10 2.998 39.835 40.412 6.437
18(F18) LC 66.7 30 0.278 12.022 12.745 9.424
  1. aBatch no 1 to 9 (LX) = Locust bean gum: Xanthan gum as a coating mixture with 10 to 30% coating level and batch no 10 to 18 (LC) = Locust bean gum: Chitosan gum as a coating mixture with 10 to 30% coating level