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Table 4 Equations for optimization of response surface method

From: Response surface method for optimization of prepared satranidazole powder layered pellets

Sl. no Name of equation Subsequent equation
1
 a Final equation in terms of coded factors for drug release at 2 h Drug release at 2 h =  + 0.99 − 0.035 * X1a − 0.80 * X2b
 b Final equation in terms of actual factors for drug release at 2 h Drug release at 2 h =  + 2.694–2.114–003 * X1a − 0.080 * X2b
2
 a Final equation in terms of coded factors for drug release at 6 h Drug release at 6 h =  + 12.13 + 3.63 * X1a − 6.95 * X2b
 b Final equation in terms of actual factors for drug release at 6 h Drug release at 6 h =  + 15.155 + 0.217 * X1a − 0.695 * X2b
3
 a Final equation in terms of coded factors for drug release difference at 10 h Drug release difference at 10 h =  + 20.29 + 8.65 * X1a − 10.91* X2b
b  Final equation in terms of actual factors for drug release difference at 10 h Drug release difference at 10 h =  + 16.198 + 0.518 * X1a − 1.090 * X2b
4
 a Final equation in terms of coded factors for mean dissolution time  Mean dissolution time =  + 9.06 − 0.40 * X1a + 0.60 * X2b
 b Final equation in terms of actual factors for mean dissolution time Mean dissolution time =  + 9.044 − 0.0239 * X1a + 0.0604* X2b
  1. aX1: ratio of coating mixture (%)
  2. bX2: coating level (%)