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Table 5 ADMET predictions by pkCSM

From: Characterization and In-silico toxicity prediction of degradation products of felbamate

Compound Intestinal absorption (%absorbed) PgP Substrate BBB Permeability (log BB) CYP1A2 inhibitor CYP2C19 inhibitor CYP2C9 Inhibitor CYP2D6 Inhibitor CYP3A4 Inhibitor AMES toxicity Hepatotoxicity
Felbamate 67.85 No − 0.206 No No No No No No Yes
DP1 96.10 No 0.516 Yes No No No No No No
DP2 95.16 No 0.125 Yes No No No Yes Yes No