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Table 4 Intra-day and inter-day precision data of DOR, LAM and TDF

From: A new stability indicating RP-UPLC method for simultaneous estimation of Doravirine, Lamivudine and Tenofovir disoproxil fumarate in bulk and their combined pharmaceutical formulation

Precision

S. no

DOR

LAM

TDF

Peak area

Peak area

Peak area

Intraday

Injection-1

268,275

1,230,225

1,172,955

Injection-2

272,409

1,238,594

1,151,322

Injection-3

271,214

1,257,594

1,130,281

Injection-4

266,268

1,230,136

1,128,429

Injection-6

268,087

1,249,456

1,143,430

 

Mean

269,788

1,239,040

1,144,274

SD

2595.8

12,055.1

16,403.3

%RSD

1.0

1.0

1.4

Inter-day

S. no

Peak area

Peak area

Peak area

Day-1

Injection-1

257,531

1,177,529

1,035,510

Injection-2

254,276

1,190,106

1,016,879

Day-2

Injection-1

252,049

1,182,299

1,048,079

Injection-2

260,733

1,172,679

1,016,808

Day-3

Injection-1

255,549

1,171,575

1,047,041

Injection-2

255,618

1,178,127

1,013,266

 

Mean

255,959

1,178,719

1,029,597

SD

2955.2

6808.3

15,955.2

%RSD

1.2

0.6

1.5

  1. S. no serial number, SD standard deviation, %RSD relative standard deviation, RT retention time, DOR Doravirine, LAM Lamivudine, TDF Tenofovir disoproxil fumarate