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Table 5 Percentage recovery results of DOR, LAM and TDF

From: A new stability indicating RP-UPLC method for simultaneous estimation of Doravirine, Lamivudine and Tenofovir disoproxil fumarate in bulk and their combined pharmaceutical formulation

DRUG

Level of addition

Amount added

Drug found (µg/mL)

Average % recovery

%RSD

(%)

(µg/mL)

Mean ± SD

Mean ± SD

 

DOR

50

25

24.93 ± 0.222

99.74 ± 0.601

0.603

100

50

49.81 ± 0.289

150

75

74.91 ± 0.385

LAM

50

75

74.103 ± 0.791

99.01 ± 0.745

0.752

100

150

149.167 ± 0.077

150

225

222.264 ± 1.864

TDF

50

75

75.39 ± 0.638

100.05 ± 0.892

0.891

100

150

149.52 ± 1.468

150

225

224.96 ± 2.162

  1. DOR Doravirine, LAM Lamivudine, TDF Tenofovir disoproxil fumarate, SD standard deviation, %RSD relative standard deviation, RT retention time, µg/mL microgram per millilitre