Table 6 Robustness results of DOR, LAM and TDF
Drug name | Variation in parameter | Peak area | %RSD | |
|---|---|---|---|---|
(mean ± SD) | ||||
DOR | Flow rate | Low | 281,144 ± 4409.7 | 1.6 |
(± 10%) | High | 190,472 ± 2766.0 | 1.5 | |
Mobile phase | Low | 230,244 ± 3529.6 | 1.5 | |
Ratio (± 10%) | High | 208,540 ± 4330.2 | 2.0 | |
Temperature (± 5%) | Low | 153,867 ± 2977.1 | 1.9 | |
High | 140,746 ± 1414.8 | 1.0 | ||
LAM | Flow rate (± 10%) | Low | 1,303,776 ± 24,862.5 | 1.9 |
High | 880,493 ± 8597.7 | 1.0 | ||
Mobile phase ratio (± 10%) | Low | 2,043,421 ± 29,466.8 | 1.4 | |
High | 1,730,444 ± 10,228.3 | 0.6 | ||
Temperature (± 5%) | Low | 592,858 ± 8755.3 | 1.5 | |
High | 584,542 ± 9847.035 | 1.7 | ||
TDF | Flow rate (± 10%) | Low | 1,329,263 ± 26,742.6 | 2.0 |
High | 1,051,959 ± 10,450.7 | 1.0 | ||
Mobile phase Ratio (± 10%) | Low | 1,135,591 ± 15,566.02 | 1.4 | |
High | 1,010,700 ± 6822.4 | 0.7 | ||
Temperature (± 5%) | Low | 614,440 ± 8254.7 | 1.3 | |
High | 594,030 ± 8543.4 | 1.4 | ||