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Table 7 Summary of degradation data of DOR, LAM and TDF

From: A new stability indicating RP-UPLC method for simultaneous estimation of Doravirine, Lamivudine and Tenofovir disoproxil fumarate in bulk and their combined pharmaceutical formulation

Degradation condition

DOR

LAM

TDF

%Deg

Peak area

%Deg

Peak area

%Deg

Peak area

Acid (0.5 N/60 °C/1 h)

4.05

258,342

4.77

1,190,261

5.19

1,085,169

Base (0.5 N/60 °C/1 h)

3.12

260,826

5.74

1,178,182

4.84

1,089,142

Oxidative (10%w/v H2O2/60 °C/1 h)

3.54

259,703

4.91

1,188,582

4.83

1,089,342

Hydrolytic (water/60 °C/1 h)

1.01

266,531

0.87

1,239,093

0.63

1,137,391

Thermal (105 °C/1 day)

1.72

264,614

1.09

1,236,328

1.02

1,132,940

Photolytic (UV radiation at 200-Wh/m2-dark control)

2.49

262,531

1.83

1,227,093

2.03

1,121,391

  1. DOR Doravirine, LAM Lamivudine, TDF Tenofovir disoproxil fumarate, h hours, % percentage, UV ultraviolet, min minute, N normality, °C degree celsius, Wh/m2 watt-hour per square metre, % Deg percentage degradation