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Fig. 5 | Future Journal of Pharmaceutical Sciences

Fig. 5

From: Marine-derived pipeline anticancer natural products: a review of their pharmacotherapeutic potential and molecular mechanisms

Fig. 5

Overview of the structures of representative marine pipeline compounds with their differential anticancer properties exhibiting various intracellular signaling pathways and molecular mechanisms to their biological targets. a and e Some compounds that inhibit the activity of microtubules and disrupting tubular polymerization, b some compounds that inhibit mitosis, c some compounds that interfere with the cell cycle and d some compounds exhibit proteasome inhibitory activity. e Some compounds inhibit GTP hydrolysis activity. Major molecular targets of marine compounds known to modulate different hallmarks of cancer by inducing apoptosis. Most of cell death hallmarks that have a mechanism involving microtubules inhibition and cell cycle arrest to induce apoptosis

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