Table 1 Variables and their levels
Types of variables | Levels | ||||
|---|---|---|---|---|---|
Low (− 1) | Medium (0) | High (+1) | − Alpha | +Alpha | |
Independent variables (CPP) | |||||
A. Drug: lipid ratio (mg) | 1:6.5 | 1:9 | 1:11.5 | 4.79 | 13.20 |
B. Surfactant: co-surfactant ratio (mg) | 1:0 | 1:1 | 1:2 | − 0.68 | 2.68 |
C. Homogenization speed (rpm) | 5000 | 7000 | 9000 | 3636.41 | 10,363.6 |
Dependent variables (CQA) | |||||
Y1. Particle size (nm) | |||||
Y2. Entrapment efficiency (%) | |||||
Y3. Drug loading (%) | |||||