Table 1 Chemical name of Diltiazem and its impurities
Compound name | Chemical name | Molecular weight |
|---|---|---|
Diltiazem hydrochloride | 3-(Acetyloxy)-5-[2-(dimethylamino) ethyl]-2, 3-dihydro-2-(4-methoxyphenyl)-1, 5-benzothiazepin -4(5H)-one monohydrochloride | 450.98 |
Diltiazem EP impurity-A | (2R,3S)-5-[2-(dimethylamino) ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-3-yl acetate | 414.52 |
Diltiazem EP impurity-B | (2S,3S)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1, 5-benzothiazepine-3-yl acetate | 343.40 |
Diltiazem EP impurity-C | (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-hydroxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate | 400.49 |
Diltiazem EP impurity-E | (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5- benzothiazepin-4(5H)-one | 301.36 |
Diltiazem EP impurity-F | (2S,3S)-5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | 372.5 |