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Table 6 Limit of quantification, detection and response factor (LOQ, LOD and RF)

From: A novel stability-indicating method for known and unknown impurities profiling for diltiazem hydrochloride pharmaceutical dosage form (tablets)

Compound

LOQ

LOD

RF

µg mL−1

%w/wa

µg mL−1

%w/wa

EP impurity-F

0.18

0.015

0.06

0.005

0.82

Diltiazem hydrochloride

0.12

0.01

0.04

0.003

1.00

  1. a%w/w calculated with respect to sample concentration (1200 µg mL−1)