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Table 8 Stress degradation results

From: Method development and validation for Cabotegravir and Rilpivirine by using HPLC and its degradants are characterized by LCMS and FTIR

Results: % degradation results

Rilpivirine

Cabotegravir

Number of DPs formed

Area

% degradation

Area

% degradation

 

Control

2,535,823

0

1,335,136

0.1

Reduction

2,277,678

12.2

1,190,347

13.9

Base

2,244,102

12.5

1,173,639

12.1

DP3

Acid

2,208,598

16.5

1,161,321

15.3

DP1 and DP2

Thermal

2,197,980

11.4

1,150,247

10.9

Photo

2,176,871

10.2

1,138,264

12.8

Peroxide

2,114,687

13.5

1,335,136

13

DP4