Pharmacokinetics properties | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
GI absorption | BBB permeation | Log p o/w | P-gp | Inhibition of cytochrome P450 | Log Kp | |||||
CYP1A2 | CYP2C19 | CYP2C9 | CYP3A4 | CYP2D6 | ||||||
1a | High | Yes | 4.81 | Yes | × | √ | √ | × | √ | − 4.99 cm/s |
1b | High | Yes | 4.71 | Yes | × | √ | √ | √ | √ | − 5.41 cm/s |
1c | High | Yes | 1.64 | Yes | × | × | × | √ | × | − 6.87 cm/s |
1d | High | Yes | 3.36 | Yes | √ | √ | √ | √ | √ | − 6.15 cm/s |