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Table 5 Pharmacokinetic studies of pterocarpans

From: Pharmaco-chemical profiling of Desmodium gangeticum (L.) DC. with special reference to soil chemistry

Pharmacokinetics properties
GI absorption BBB permeation Log p o/w P-gp Inhibition of cytochrome P450 Log Kp
CYP1A2 CYP2C19 CYP2C9 CYP3A4 CYP2D6
1a High Yes 4.81 Yes × × − 4.99 cm/s
1b High Yes 4.71 Yes × − 5.41 cm/s
1c High Yes 1.64 Yes × × × × − 6.87 cm/s
1d High Yes 3.36 Yes − 6.15 cm/s
  1. 1a, gangetin; 1b, gangetinin;, 1c, desmocarpin; 1d, desmodin; GI, gastrointestinal absorption; BBB, blood–brain barrier permeability; Log Po/w, lipophilicity; P-gp, P-glycoprotein substrate; Log Kp, skin permeation