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Table 5 Pharmacokinetic studies of pterocarpans

From: Pharmaco-chemical profiling of Desmodium gangeticum (L.) DC. with special reference to soil chemistry

Pharmacokinetics properties

GI absorption

BBB permeation

Log p o/w

P-gp

Inhibition of cytochrome P450

Log Kp

CYP1A2

CYP2C19

CYP2C9

CYP3A4

CYP2D6

1a

High

Yes

4.81

Yes

×

√

√

×

√

− 4.99 cm/s

1b

High

Yes

4.71

Yes

×

√

√

√

√

− 5.41 cm/s

1c

High

Yes

1.64

Yes

×

×

×

√

×

− 6.87 cm/s

1d

High

Yes

3.36

Yes

√

√

√

√

√

− 6.15 cm/s

  1. 1a, gangetin; 1b, gangetinin;, 1c, desmocarpin; 1d, desmodin; GI, gastrointestinal absorption; BBB, blood–brain barrier permeability; Log Po/w, lipophilicity; P-gp, P-glycoprotein substrate; Log Kp, skin permeation