Screening assessment of trimethoxy flavonoid and - (-)-epigallocatechin-3-gallate against formalin-induced arthritis in Swiss albino rats and binding properties on NF-κB-MMP9 proteins

Future Journal of Pharmaceutical Sciences

Table 1 Docking analysis of TMF and EGCG

Targeted proteins	Trimethoxy flavone			(-)-Epigallocatechin gallate
Targeted proteins	Binding affinities of phytocompound with target proteins (Kcal/mol)-AutoDock	Interactions of docked complexes	Inhibitory constant (IC₅₀)	Binding affinities of phytocompound with target proteins (Kcal/mol)-AutoDock	Interactions of docked complexes	Inhibitory constant (IC₅₀)
1BFT	− 5.69	Arg-201, Asp-210, Asn-200, Glu-211	67.34 µM	− 7.82	Ser-203, Arg-201, Glu-211, Asn-200, Asp-210, Phe-213 and Ile-212	1.85 µM
6ESM	− 6.18	Leu-188, Ala-189, Pro-246, Tyr-248, Met-247 and Gly-186	29.56 µM	− 9.77	Lys-184, Asp-185, Glu-208, Leu-209, Gly-217, Tyr-218, Lys-214, Gly-213, Phe-250 and Tyr-248	69.14 nM