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Table 6 Results for robustness study

From: Stability indicating RP-UPLC method for simultaneous quantification of bempedoic acid and ezetimibe in bulk and pharmaceutical formulations

Chromatographic changes *Peak area Tailing Factor Theoretical Plates *Assay (% w/w) ± SD, % RSD
   BA EZ BA EZ BA EZ BA EZ
Flow rate ± 0.1 (mL/min.) 0.4 45,118,072 12,608,841 1.184 1.407 3588 9450 100.59 ± 0.1799, 0.18 99.91 ± 0.3205, 0.32
  0.5 44,965,324 12,588,406 1.172 1.166 3041 7911   
  0.6 45,051,231 12,583,731 1.144 1.123 2455 7299   
Temperature ± 5 (°C) 20 45,036,493 12,584,203 1.155 1.163 3481 9827 100.51 ± 0.2184, 0.22 99.88 ± 0.4116, 0.41
  25 44,906,494 12,580,784 1.181 1.173 3112 8067   
  30 45,086,495 12,612,046 1.108 1.122 2484 6857   
Detection wavelength ± 2 (nm) 258 44,934,914 12,597,848 1.153 1.141 3585 9708 100.53 ± 0.1820, 0.18 99.60 ± 0.3573, 0.34
  260 45,040,389 12,569,963 1.158 1.174 3088 8102   
  262 45,085,863 12,574,861 1.134 1.128 2548 6989   
  1. *Mean of three determinations; SD = Standard Deviation; RSD = Relative Standard Deviation