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Table 5 Variables in 32 optimal response surface designs for pellets

From: Development and characterization of multiparticulate system as an alternative to unit dosage forms containing drugs with diverse release profiles

Independent variables Levels
Low Medium High
MFH pellets
X1 = Carbopol 971 (mg) 125 250 375
X2 = Avicel PH 101(mg) 248.5 342.25 436.0
GMP and PGH pellets
X1 = Pharmatose 200 M 63.5 80.0 92.5
X2 = Primogel 1.0 2.5 5.0
Dependent variables (Response)
Y1 = Drug content    
Y2 = In vitro drug release