Table 5 Variables in 32 optimal response surface designs for pellets
Independent variables | Levels | ||
|---|---|---|---|
Low | Medium | High | |
MFH pellets | |||
X1 = Carbopol 971 (mg) | 125 | 250 | 375 |
X2 = Avicel PH 101(mg) | 248.5 | 342.25 | 436.0 |
GMP and PGH pellets | |||
X1 = Pharmatose 200 M | 63.5 | 80.0 | 92.5 |
X2 = Primogel | 1.0 | 2.5 | 5.0 |
Dependent variables (Response) | |||
Y1 = Drug content | |||
Y2 = In vitro drug release | |||