Fig. 12
The particle size distribution of the prepared batches of microspheres. The enhancement of the size of microspheres can be related to the growth in viscosity of the polymeric solution as the concentration was elevated. This elevation in viscosity, in turn, increases the droplet size when the polymer-drug mixture was added to the cross-linking solution, thereby resulting in a larger size of particles. Moreover, as the concentration of the cross-linking agent (CaCl2) was increased; a gradual decrease in the size of the microsphere was noticed