Fig. 7

Gamma Scintigraphy Imaging of radio-labelled microspheres in rabbits was done using two groups each consisting three animals. The SPECT CT imaging clearly depicted the retention of the formulation in the stomach and upper part of intestine thereby releasing the drug materials from there. A The scintigram represents the initial position of the radiolabelled formulation at time 0 h. From the image, the location of the dosage form can be clearly seen and almost negligible amount of drug is released at the given time. B The scintigram obtained after time 1 h clearly represents the location of the dosage form with the subsequent release of the drug from that specific area as indicated by the dark colour dots. C At time interval of 4 h, the scintigram obtained shows the presence of the dosage form in the same location within the GI tract with further drug release from there this justifies the mucoadhesive nature of the prepared microsphere formulation. D The scintigram obtained at time interval of 6 h gives the further indication of the location of the formulation which supports the design concept of this current study. It can be clearly seen that the drug is still adhered to the mucosal lining in the upper part of intestine with the active medicament slowly releasing from there