Fig. 8

The STZ diabetic model used for estimation of the effective nature of the prepared microsphere is resembled here. As seen in the red line, there was no such enhancement of serum blood glucose level when estimated at different time interval of 0 days, 3 days, 10 days, 17 days and 24 days. The blue line indicates the gradual increase in serum blood glucose level at different time interval for the STZ treated group (A). Similarly, the black line and the yellow line represent the effectiveness of the standard drug glibenclamide and the prepared MSB-Starch microsphere loaded with gliclazide, respectively, in controlling the serum blood glucose level when estimated in the given time interval. The effect of the microsphere on the lipid profile like total cholesterol, triglycerides, HDL-c and LDL-c is represented here. There was a subsequent increase in the total cholesterol, triglycerides, LDL-c level with the overall decrease in the HDL-c level as seen in the STZ treated group represented by the red block (B). There was no such alteration in the above parameters in the normal group as seen in the blue block. The green and violet block represents the effectiveness of the standard drug glibenclamide and the prepared microsphere in the management of the lipid profile