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Table 1 Response parameters

From: Pharmacoscintigraphic evaluation and antidiabetic efficacy of gliclazide-loaded 99mTc-labelled mucoadhesive microspheres

Std Run Factor 1 (X1) Factor 2 (X2) Response 1 Response 2 Response 3
A: polymer B: cross-linking agent DL BA DR
gm gm % % %
1 1 3(− 1) 2(− 1) 63.77 69.12 97.44
9 2 9(+ 1) 6(+ 1) 75.42 80.10 76.87
8 3 6(0) 6(+ 1) 79.37 82.13 78.87
6 4 9(+ 1) 4(0) 70.12 86.22 75.40
2 5 6(0) 2(− 1) 60.23 73.19 90.55
4 6 3(− 1) 4(0) 74 72.11 88.66
5 7 6(0) 4(0) 71.40 78.10 81.10
7 8 3(− 1) 6(+ 1) 80.72 76.50 81.20
3 9 9(+ 1) 2(− 1) 57.40 81.50 86.25
  1. Polymer: Musa balbisiana starch: Sodium alginate (1:1 in all formulation); Cross-linking agent: Calcium chloride; DL: Drug Loading; BA: Bio adhesion; DR: Drug release
  2. Coded values are in bracket; (X1) and (X2) are independent factors; (+ 1) = higher values; (0) = medium value and (− 1) = lower values